Peptide Profile

MOTS-c — A Mitochondrial powerhouse for metabolism, performance & healthy aging. Unlock cleaner energy, more consistent glucose management, and enhanced stamina. MOTS-c is a peptide encoded by the mitochondria that activates AMPK, optimizes energy usage, enhances insulin sensitivity, and helps you train harder while recovering faster—while simultaneously reducing inflammation and cellular stress responses associated with aging.

• Peptide Name: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
• CAS Number: 1627580-64-6
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂ (free peptide)
• Primary Function: Regulator of metabolism; AMPK activation; mimicking exercise effects
• Mechanism of Action:
  • In skeletal muscle, MOTS-c inhibits the folate/purine pathway → resulting in increased endogenous AICAR → leading to AMPK activation → which improves glucose uptake and fat oxidation.
  • In stressful situations, MOTS-c moves to the nucleus and interacts with stress-response programs (including NRF2-linked antioxidant genes), helping to coordinate resilience.

Key Features & Benefits

• Enhances insulin sensitivity and proper glucose handling
• Increases training capacity and muscular performance
• Facilitates fat utilization and supports favorable body composition
• Boosts mitochondrial efficiency and resilience against cellular stress
• Offers broad support for healthy aging through AMPK/NRF2 pathways

Who Benefits Most:

• Athletes & highly active individuals looking for endurance, work capacity, and recovery
• People focused on body recomposition and metabolic wellness
• Longevity enthusiasts optimizing energy at the cellular level and enhancing stress defenses

Effects on Key Areas:

• Blood sugar & insulin: Enhances insulin sensitivity and uptake mechanisms
• Endurance & performance: Boosts physical performance in animal studies; MOTS-c levels increase with human exercise
• Body composition: Encourages fat oxidation and improved metabolic signaling
• Recovery & inflammation: Activates NRF2-mediated antioxidant responses
• Cellular/mitochondrial function: Supports proteostasis and adaptability to stress